Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818006 | 0.75 | HTR1A (0.48) | HTR1ADRD2HTR2ADRD3ADRA2A | |
| SCHEMBL8011318 | 0.72 | DRD2 (0.69) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL27360459 | 0.68 | DRD2 (0.60) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL7821213 | 0.68 | GRIN1 (0.50) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL27260845 | 0.68 | PARP1 (0.33) | — | |
| SCHEMBL2095204 | 0.67 | DRD2 (0.58) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL10661045 | 0.67 | DRD2 (0.58) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL28918989 | 0.67 | DRD2 (0.58) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL7653085 | 0.67 | CYP2D6 (0.70) | HTR1ADRD2HTR2ADRD3DRD1 | |
| SCHEMBL8223307 | 0.67 | KDM4E (0.62) | HTR1ADRD2HTR2ADRD3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111886025-A | Use of serotonergic agents for the treatment of virus-induced thrombocytopenia | 新加坡国立大学 | 2020-11-03 | — | — | CN | claimed |
| CN-111886025-A | Use of serotonergic agents for the treatment of virus-induced thrombocytopenia | 新加坡国立大学 | 2020-11-03 | — | — | CN | disclosed |