Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28475115 | 0.87 | MAPT (0.55) | ALDH1A1CYP11B1CYP11B2MAPTTP53 | |
| SCHEMBL28469317 | 0.86 | MAPT (0.55) | ALDH1A1TRIM24TRIM33MAPTTP53 | |
| SCHEMBL18001863 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TRIM24TRIM33CYP11B1CYP11B2 | |
| SCHEMBL28477104 | 0.80 | ALDH1A1 (0.57) | ALDH1A1TRIM24TRIM33MAPTTP53 | |
| SCHEMBL28239182 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TRIM24TRIM33MAPTTP53 | |
| SCHEMBL1244152 | 0.79 | ALDH1A1 (0.55) | ALDH1A1TRIM24TRIM33MAPTRAB9A | |
| SCHEMBL28469757 | 0.77 | ALDH1A1 (0.54) | ALDH1A1TRIM24TRIM33CYP11B1CYP11B2 | |
| SCHEMBL9400665 | 0.77 | VEGFA (0.56) | ALDH1A1TRIM24TRIM33CYP11B1CYP11B2 | |
| SCHEMBL28480628 | 0.77 | ALDH1A1 (0.62) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18002126 | 0.76 | KDM4E (0.51) | ALDH1A1MAPTTP53LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108358923-B | Sophoridine pyrrole and indole derivatives, and preparation method and application thereof | 广西大学 | 2020-11-03 | — | — | CN | claimed |
| CN-108047226-B | Matrine pyrrole and indole derivatives, and preparation method and application thereof | 广西大学 | 2020-11-03 | — | — | CN | claimed |