Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.48 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829620 | 0.94 | HRH3 (0.53) | HRH3VCPL3MBTL1RAB9AP2RY12 | |
| SCHEMBL2828583 | 0.84 | HRH3 (0.46) | HRH3L3MBTL1RAB9AKDM4EMAPT | |
| SCHEMBL2857095 | 0.83 | ALDH1A1 (0.47) | HRH3L3MBTL1RAB9AP2RY12KDM4E | |
| SCHEMBL2847900 | 0.82 | LCK (0.46) | HRH3L3MBTL1RAB9AKDM4EMAPT | |
| SCHEMBL1476237 | 0.78 | OGA (0.57) | HRH3HDAC4OGA | |
| SCHEMBL2868151 | 0.78 | FGFR3 (0.49) | HRH3L3MBTL1RAB9AKDM4EMAPT | |
| Cyclohexane SCHEMBL2828762 | 0.78 | L3MBTL1 (0.52) | HRH3L3MBTL1RAB9AKDM4EMAPT | |
| SCHEMBL2854266 | 0.77 | HRH3 (0.43) | HRH3KDM4EMAPT | |
| SCHEMBL2829488 | 0.76 | ALDH1A1 (0.52) | HRH3L3MBTL1RAB9AP2RY12KDM4E | |
| SCHEMBL7887534 | 0.75 | SMN1; SMN2 (0.67) | HRH3RAB9AP2RY12KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824829-B1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-05-05 | — | — | EP | disclosed |