Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1190993 | 0.75 | CYP3A4 (0.39) | LMNAALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL21825342 | 0.73 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL14881906 | 0.73 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL20320658 | 0.73 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL1717495 | 0.72 | ALDH1A1 (0.36) | LMNAALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL25424053 | 0.69 | ALDH1A1 (0.34) | LMNAALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL22982776 | 0.69 | MEN1 (0.39) | LMNAALDH1A1MEN1KMT2AGRIN2B | |
| SCHEMBL22982851 | 0.68 | CPB2 (0.39) | LMNAALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL28665811 | 0.68 | — | — | |
| SCHEMBL12612018 | 0.67 | HPGD (0.42) | LMNAALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111918651-B | GCN2 inhibitors and uses thereof | 默克专利股份有限公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-111918651-A | GCN2 inhibitors and uses thereof | 默克专利股份有限公司 | 2020-11-10 | — | — | CN | disclosed |