Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 4/20 | 0.49 |
| ▸ | AR | P10275 | 6/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | PDE6D | O43924 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412059 | 1.00 | CFTR (0.50) | CFTRPARP1ARPKN1PKN2 | |
| SCHEMBL28493353 | 0.90 | CFTR (0.56) | CFTRPARP1PKN1PKN2PLA2G2A | |
| SCHEMBL29412022 | 0.90 | CFTR (0.56) | CFTRPARP1PKN1PKN2PLA2G2A | |
| SCHEMBL28487665 | 0.88 | PKN1 (0.56) | PARP1PKN1PKN2MAPTPDE6D | |
| SCHEMBL29412017 | 0.88 | PKN1 (0.56) | PARP1PKN1PKN2MAPTPDE6D | |
| SCHEMBL28478408 | 0.86 | ALDH1A1 (0.58) | PARP1PKN1PKN2MAPTHTT | |
| SCHEMBL29412060 | 0.86 | PKN1 (0.54) | PARP1PKN1PKN2KMT2AKDM4E | |
| SCHEMBL28484147 | 0.85 | PARP1 (0.51) | PARP1PKN1PKN2KMT2AKDM4E | |
| SCHEMBL29411964 | 0.85 | PARP1 (0.51) | PARP1PKN1PKN2KMT2AKDM4E | |
| SCHEMBL29829700 | 0.84 | CFTR (0.55) | CFTRARMAPTHTTPDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978301-B | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2022-08-02 | — | — | CN | disclosed |
| CN-111978301-A | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2020-11-24 | — | — | CN | disclosed |