Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PI4KA | P42356 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703399 | 0.85 | LRRK2 (0.40) | KDM5AKITJAK2LRRK2MPO | |
| SCHEMBL1703270 | 0.85 | LRRK2 (0.40) | KDM5AKITJAK2LRRK2MPO | |
| SCHEMBL12598741 | 0.85 | LRRK2 (0.40) | KDM5AKITJAK2LRRK2MPO | |
| SCHEMBL1422774 | 0.81 | MET (0.41) | KDM5AJAK2LRRK2MPOMET | |
| SCHEMBL15652587 | 0.79 | BMPR1A (0.37) | KDM5AKITJAK2LRRK2MPO | |
| SCHEMBL173506 | 0.78 | — | — | |
| SCHEMBL2574462 | 0.77 | KIT (0.48) | KDM5AKITJAK2LRRK2MPO | |
| Hydrochloric Acid SCHEMBL25243994 | 0.76 | PIK3CD (0.41) | KDM5AMPOPIK3CDPIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL31507950 | 0.76 | PIK3CD (0.41) | KDM5AMPOPIK3CDPIK3CAPIK3CB | |
| SCHEMBL10282490 | 0.73 | ACHE (0.46) | KDM5AJAK2MPOPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825656-B | Inhibitors of protein arginine methyltransferase 5 (PRMT 5), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-111825656-A | Inhibitors of protein arginine methyltransferase 5(PRMT5), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2020-10-27 | — | — | CN | disclosed |