SCHEMBL28486374

SCHEMBL28486374

O=C(O)c1ccc(Cc2cc(-c3ccncc3)ccn2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 3/20 0.48
NAPRT Q6XQN6 1/20 0.46
LOXL2 Q9Y4K0 1/20 0.43
GSK3B P49841 2/20 0.43
RHEB Q15382 1/20 0.43
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
CYP3A4 P08684 2/20 0.42
CYP19A1 P11511 2/20 0.42
CYP11B1 P15538 2/20 0.42
CYP11B2 P19099 2/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
KDM5A P29375 2/20 0.40
KDM4C Q9H3R0 2/20 0.40
KDM5B Q9UGL1 2/20 0.40
ROCK2 O75116 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28404833 0.99 CYP17A1 (0.47) CYP17A1NAPRTLOXL2GSK3BRHEB
Hydrochloric Acid SCHEMBL29279098 0.87 NAPRT (0.41) CYP17A1NAPRTLOXL2GSK3BKDM5A
SCHEMBL28243748 0.81 NOTUM (0.48) CYP17A1GSK3BCYP3A4CYP19A1CYP11B1
Bromide SCHEMBL30008835 0.80 FYN (0.47) CYP17A1GSK3BCYP3A4CYP19A1CYP11B1
SCHEMBL28133235 0.78 CYP17A1 (0.42) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
SCHEMBL18906031 0.77 HDAC1 (0.65) CYP17A1NAPRTCA12CA1CA2
Hydrochloric Acid SCHEMBL28477394 0.77 CYP17A1 (0.41) CYP17A1CYP3A4CYP19A1CYP11B1CYP11B2
Terephthalic Acid SCHEMBL17360384 0.77 NAPRT (0.76) NAPRTGSK3BCA12CA1CA2
SCHEMBL28493105 0.75 LOXL2 (0.59) NAPRTLOXL2GSK3BHDAC1HDAC6
SCHEMBL205344 0.75 NAPRT (0.73) NAPRTGSK3BCA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108658849-B Cr (III) complex and preparation method and application thereof 太原师范学院 2021-08-13 CN claimed
CN-107522722-B Double-insertion Zn (II) complex for inkless and erasable printing and preparation method thereof 淮阴师范学院 2020-12-01 CN claimed
CN-107522722-B Double-insertion Zn (II) complex for inkless and erasable printing and preparation method thereof 淮阴师范学院 2020-12-01 CN disclosed