Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 9/20 | 0.41 |
| ▸ | CDK2 | P24941 | 9/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.41 |
| ▸ | PDE8A | O60658 | 3/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161963 | 0.86 | ADORA2A (0.49) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL29426182 | 0.78 | CDK2 (0.56) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL539356 | 0.78 | CDK2 (0.56) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL27897027 | 0.75 | CDK2 (0.44) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL25211412 | 0.75 | P2RX7 (0.41) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL2848870 | 0.74 | AHR (0.50) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL30331956 | 0.73 | ADORA2A (0.50) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL946328 | 0.73 | ADORA2A (0.50) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL5440560 | 0.72 | CDK2 (0.43) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL1913380 | 0.71 | CDK1 (0.41) | CCNA2CDK2CCNA1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2010056907-A2 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130476-A1 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | IAPP, PNLIP, GPR119 | CCNA2 66/4885CDK2 128/4885CCNA1 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.