Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.30 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17032187 | 0.72 | ACE (0.37) | ACEPIK3CDPER2 | |
| SCHEMBL11480660 | 0.70 | ACE (0.39) | ACEPIK3CDPER2CRY2 | |
| SCHEMBL27653286 | 0.68 | TSHR (0.41) | ACEPIK3CD | |
| SCHEMBL6654051 | 0.68 | HSD11B1 (0.56) | ACE | |
| SCHEMBL6654054 | 0.68 | HSD11B1 (0.56) | ACE | |
| SCHEMBL6654048 | 0.68 | HSD11B1 (0.56) | ACE | |
| SCHEMBL15468337 | 0.68 | PER2 (0.40) | ACEPIK3CDPER2CRY2 | |
| SCHEMBL28306716 | 0.65 | ACE (0.38) | ACE | |
| SCHEMBL1671623 | 0.64 | BRD4 (0.38) | PER2 | |
| SCHEMBL1671844 | 0.64 | BRD4 (0.38) | PER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458912-B | Bicyclic fused heteroaryl or aryl compounds and their use as IRAK4 mimetics | 辉瑞公司 | 2020-10-27 | — | — | CN | disclosed |
| CN-106458912-A | Bicyclic fused heteroaryl or aryl compounds and their use as IRAK4 mimetics | 辉瑞公司 | 2017-02-22 | — | — | CN | disclosed |