Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | STAT1 | P42224 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28903919 | 0.80 | EGFR (0.55) | EGFRFGFR1ERBB3RAF1BRAF | |
| SCHEMBL374439 | 0.80 | EGFR (0.72) | EGFRFGFR1ERBB3NPC1RAB9A | |
| SCHEMBL374158 | 0.79 | FGFR3 (0.77) | EGFRFGFR1ERBB3FGFR3 | |
| SCHEMBL28495163 | 0.76 | EGFR (0.58) | EGFRFGFR1ERBB3NPC1RAB9A | |
| SCHEMBL28261624 | 0.75 | EGFR (1.00) | EGFRFGFR1ERBB3NPC1RAB9A | |
| SCHEMBL28498357 | 0.75 | EGFR (0.66) | EGFRFGFR1ERBB3NPC1RAB9A | |
| SCHEMBL5814747 | 0.74 | MAPK10 (0.61) | EGFRFGFR1ERBB3NPC1RAB9A | |
| SCHEMBL374665 | 0.73 | FGFR3 (0.64) | EGFRFGFR1ERBB3NPC1RAB9A | |
| SCHEMBL373717 | 0.73 | EGFR (0.80) | EGFRFGFR1ERBB3NPC1RAB9A | |
| SCHEMBL5752852 | 0.72 | MEN1 (0.62) | NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053594-B | 1- (3, 5-dimethoxyphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-18 | — | — | CN | disclosed |