Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
| ▸ | ERBB3 | P21860 | 6/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28903919 | 0.84 | EGFR (0.55) | EGFRFGFR1ERBB3 | |
| SCHEMBL28498357 | 0.82 | EGFR (0.66) | EGFRFGFR1ERBB3FGFR3MAPT | |
| SCHEMBL28490668 | 0.76 | EGFR (0.60) | EGFRFGFR1ERBB3FGFR3MAPT | |
| SCHEMBL374439 | 0.76 | EGFR (0.72) | EGFRFGFR1ERBB3FGFR3MAPT | |
| SCHEMBL28260312 | 0.73 | EGFR (1.00) | EGFRFGFR1ERBB3LCKFGFR3 | |
| SCHEMBL374876 | 0.72 | EGFR (0.71) | EGFRFGFR1ERBB3FGFR3MAPT | |
| SCHEMBL28497440 | 0.72 | EGFR (0.60) | EGFRFGFR1ERBB3FGFR3MAPT | |
| SCHEMBL28261624 | 0.71 | EGFR (1.00) | EGFRFGFR1ERBB3LCKFGFR3 | |
| SCHEMBL28489977 | 0.71 | EGFR (0.60) | EGFRFGFR1ERBB3FGFR3MAPT | |
| SCHEMBL374158 | 0.71 | FGFR3 (0.77) | EGFRFGFR1ERBB3LCKFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053594-B | 1- (3, 5-dimethoxyphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-18 | — | — | CN | disclosed |