Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 11/20 | 0.49 |
| ▸ | BRAF | P15056 | 6/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | NEK4 | P51957 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.46 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28495163 | 0.84 | EGFR (0.58) | EGFRFGFR1ERBB3 | |
| SCHEMBL28905573 | 0.82 | EGFR (0.75) | EGFRFGFR1ERBB3RAF1BRAF | |
| SCHEMBL28498357 | 0.80 | EGFR (0.66) | EGFRFGFR1ERBB3 | |
| SCHEMBL28490668 | 0.80 | EGFR (0.60) | EGFRFGFR1ERBB3RAF1BRAF | |
| SCHEMBL31440788 | 0.74 | KMT2A (0.61) | RAF1BRAF | |
| SCHEMBL374439 | 0.73 | EGFR (0.72) | EGFRFGFR1ERBB3 | |
| SCHEMBL4243486 | 0.73 | RAF1 (0.61) | RAF1BRAFKDR | |
| SCHEMBL8368359 | 0.72 | MAPT (0.56) | RAF1BRAF | |
| SCHEMBL1463480 | 0.71 | MAPT (0.67) | BRAFKDR | |
| SCHEMBL5368898 | 0.71 | KDM4E (0.71) | FGFR1RAF1BRAFKDRCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053594-B | 1- (3, 5-dimethoxyphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-18 | — | — | CN | claimed |
| CN-109053594-B | 1- (3, 5-dimethoxyphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-18 | — | — | CN | disclosed |