Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831874 | 0.92 | KDM4E (0.41) | KDM4EGAAHRH3KMT2AMEN1 | |
| SCHEMBL2825670 | 0.85 | ALDH1A1 (0.45) | KDM4EHRH3KMT2AMEN1CXCR3 | |
| SCHEMBL2829721 | 0.84 | GAA (0.52) | GPR119KDM4EGAAHRH3HSD17B10 | |
| SCHEMBL4951044 | 0.84 | SLC6A9 (0.42) | SLC6A9KDM4EHRH3KMT2AMEN1 | |
| SCHEMBL2824631 | 0.84 | L3MBTL1 (0.48) | KDM4EGAAHRH3KMT2AMEN1 | |
| SCHEMBL2827890 | 0.84 | HRH3 (0.39) | KDM4EGAAHRH3KMT2AMEN1 | |
| SCHEMBL2829310 | 0.81 | ALDH1A1 (0.51) | KDM4EHRH3KMT2AMEN1HSD17B10 | |
| SCHEMBL2825973 | 0.79 | ALDH1A1 (0.48) | GPR119KMT2AMEN1HSD17B10CXCR3 | |
| SCHEMBL2828081 | 0.79 | TP53 (0.46) | GPR119HRH3HSD17B10CXCR3ALDH1A1 | |
| SCHEMBL2826534 | 0.79 | HRH3 (0.46) | KDM4EHRH3CXCR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824829-B1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-05-05 | — | — | EP | claimed |