Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31582535 | 0.88 | POLB (0.67) | POLBALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL7244671 | 0.73 | ALDH1A1 (0.51) | ALDH1A1HSD17B10KDM4EHPGDALOX5 | |
| SCHEMBL28494955 | 0.72 | ALDH1A1 (0.51) | POLBALDH1A1KDM4EHPGDPKM | |
| SCHEMBL31582377 | 0.69 | POLB (0.66) | POLBALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL31582291 | 0.69 | POLB (0.65) | POLBALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7978506 | 0.69 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4EHPGDALOX5 | |
| SCHEMBL7978560 | 0.68 | NPSR1 (0.52) | POLBALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL28500185 | 0.67 | ALDH1A1 (0.38) | POLBALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL30738275 | 0.67 | POLB (0.62) | POLBALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL31582421 | 0.66 | ALDH1A1 (0.54) | POLBALDH1A1KDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108467386-B | Fused heteroaryl substituted 1,2, 4-triazine-3-amine derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2020-11-17 | — | — | CN | disclosed |