Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28495204 | 0.90 | HDAC1 (0.60) | HDAC1HDAC6POLBL3MBTL1KDM4E | |
| SCHEMBL28504884 | 0.81 | HDAC6 (0.75) | HDAC1HDAC6MEN1POLBMAPT | |
| SCHEMBL28509075 | 0.79 | HDAC6 (1.00) | HDAC1HDAC6MEN1POLBMAPT | |
| SCHEMBL29558498 | 0.74 | HDAC6 (0.71) | HDAC1HDAC6MEN1POLBMAPT | |
| SCHEMBL29558554 | 0.73 | HDAC6 (0.66) | HDAC1HDAC6MEN1POLBMAPT | |
| SCHEMBL15255066 | 0.71 | KCNA3 (0.39) | MEN1KMT2A | |
| SCHEMBL29558406 | 0.71 | CCR5 (0.34) | HDAC1HDAC6MEN1KMT2A | |
| SCHEMBL29558905 | 0.69 | HDAC1 (0.72) | HDAC1HDAC6MEN1POLBMAPT | |
| SCHEMBL28502726 | 0.68 | HDAC1 (0.70) | HDAC1HDAC6MEN1POLBMAPT | |
| SCHEMBL29558833 | 0.68 | HDAC1 (0.60) | HDAC1HDAC6MEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111943892-B | Histone deacetylase subtype inhibitor thioacetylarylamine compound and application thereof | 上海中泽医药科技有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-111943892-A | Histone deacetylase subtype inhibitor thioacetylarylamine compound and application thereof | 上海中泽医药科技有限公司 | 2020-11-17 | — | — | CN | disclosed |