Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26138089 | 0.73 | SLC22A6 (0.75) | SLC22A6GPR84GABRR1LMNAMAPT | |
| SCHEMBL16028458 | 0.72 | LMNA (0.35) | SLC22A6LMNA | |
| SCHEMBL3089526 | 0.71 | SLC22A6 (0.71) | SLC22A6GPR84GABRR1LMNAMAPT | |
| SCHEMBL27544066 | 0.70 | SLC22A6 (0.55) | SLC22A6GPR84GABRR1LMNAMAPT | |
| SCHEMBL21244722 | 0.69 | DGAT1 (0.32) | — | |
| SCHEMBL21275047 | 0.69 | SLC22A6 (0.37) | SLC22A6GABRR1LMNASMN1; SMN2 | |
| SCHEMBL112368 | 0.68 | SLC22A6 (1.00) | SLC22A6GPR84GABRR1LMNAMAPT | |
| SCHEMBL30496763 | 0.68 | SLC22A6 (1.00) | SLC22A6GPR84GABRR1LMNAMAPT | |
| SCHEMBL597917 | 0.68 | GPR84 (0.59) | SLC22A6GPR84GABRR1LMNAMAPT | |
| SCHEMBL16877059 | 0.68 | CYP2C19 (0.38) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285547-A | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-112004817-B | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-112004817-A | Macrocyclic compounds as modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions thereof, their use in the treatment of cystic fibrosis, and processes for their preparation | 弗特克斯药品有限公司 | 2020-11-27 | — | — | CN | disclosed |