Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28510243 | 0.83 | RAB9A (0.42) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL28503323 | 0.79 | ALDH1A1 (0.49) | ALDH1A1HTTSMN1; SMN2HPGDPOLB | |
| SCHEMBL2293283 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HTTSMN1; SMN2HPGDPARP10 | |
| SCHEMBL28510306 | 0.77 | MAOB (0.54) | NPC1RAB9AMAOBMAOACDK4 | |
| SCHEMBL1200712 | 0.76 | SMN1; SMN2 (0.50) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5322086 | 0.74 | NR4A2 (0.45) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL28497262 | 0.74 | ALDH1A1 (0.54) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1539485 | 0.74 | POLB (0.48) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1539549 | 0.74 | MAOB (0.54) | NPC1RAB9AALDH1A1HTTMAPT | |
| SCHEMBL7171456 | 0.74 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2MAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279778-B | Substituted phenoxyamide derivative, application and medicine for treating Parkinson's disease | 北京兰晟医药科技有限公司 | 2021-11-30 | — | — | CN | disclosed |
| CN-112279778-A | Substituted phenoxyamide derivative, application and medicine for treating Parkinson's disease | 岳千奥 | 2021-01-29 | — | — | CN | disclosed |
| CN-107522654-B | Novel alpha-aminoamide derivatives and medicinal use thereof | 中国人民解放军军事医学科学院毒物药物研究所 | 2020-09-01 | — | — | CN | disclosed |