Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 2/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28497081 | 0.87 | RPS6KB1 (0.35) | FGFR1CDK1IGF1RBRAFFGFR2 | |
| SCHEMBL30177935 | 0.81 | HTR3A (0.33) | MTORTLR7HTR3ARPS6KB1AKT1 | |
| SCHEMBL21733682 | 0.81 | HTR3A (0.33) | MTORTLR7HTR3ARPS6KB1AKT1 | |
| SCHEMBL21733503 | 0.77 | KRAS (0.34) | MTORTLR7HTR3AKITCYP1A2 | |
| SCHEMBL30834553 | 0.75 | HRH4 (0.38) | MTORRPS6KB1AKT1CYP1A2CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL28501326 | 0.73 | SMO (0.32) | HTR3ARPS6KB1AKT1KIT | |
| SCHEMBL24855323 | 0.71 | EPHX2 (0.34) | RPS6KB1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL21733840 | 0.69 | CYP1A2 (0.42) | CYP1A2CYP2C19USP2CYP3A4CLK4 | |
| SCHEMBL30834547 | 0.69 | CYP1A2 (0.42) | CYP1A2CYP2C19USP2CYP3A4CLK4 | |
| SCHEMBL21733667 | 0.69 | KRAS (0.45) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112119075-A | Fused ring compound | 豪夫迈·罗氏有限公司 | 2020-12-22 | — | — | CN | disclosed |