Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfamethoxazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | EDNRA | P25101 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | PPIA | P62937 | 3/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.57 |
| ▸ | EDNRB | P24530 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamethoxazole SCHEMBL3656 | 0.98 | ALDH1A1 (1.00) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL6896861 | 0.98 | ALDH1A1 (1.00) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28142856 | 0.97 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28565481 | 0.97 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL22467841 | 0.97 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL5870744 | 0.97 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL1368068 | 0.97 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL29625775 | 0.97 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL4539943 | 0.95 | ALDH1A1 (0.94) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28003342 | 0.95 | ALDH1A1 (0.94) | ALDH1A1ADRA1AMAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111771885-B | Pest control composition comprising novel iminopyridine derivatives | 株式会社MMAG | 2022-05-17 | — | — | CN | disclosed |
| CN-112244015-A | Pest control composition comprising novel iminopyridine derivatives | 明治制果药业株式会社 | 2021-01-22 | — | — | CN | disclosed |
| CN-108684667-B | Pest control composition comprising novel iminopyridine derivatives | 明治制果药业株式会社 | 2020-12-01 | — | — | CN | disclosed |