Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfamethoxazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | EDNRA | P25101 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | PPIA | P62937 | 3/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.58 |
| ▸ | EDNRB | P24530 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamethoxazole SCHEMBL3656 | 1.00 | ALDH1A1 (1.00) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28142856 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL29625775 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL22467841 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28501919 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL5870744 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL1368068 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28565481 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL4539943 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28003342 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ADRA1AMAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344325-A1 | LOCAL ADMINISTRATION OF DRUGS FOR THE TREATMENT OF ASTHMA | Mercator Medsystems, Inc. (US) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017040605-A1 | LOCAL ADMINISTRATION OF DRUGS FOR THE TREATMENT OF ASTHMA | MERCATOR MEDSYSTEMS, INC. (US) | 2017-03-09 | — | — | WO | disclosed |
| EP-2181330-B2 | COMPOSITIONS AND MEANS FOR DIAGNOSING MICROBIAL INFECTIONS | STATENS SERUMINSTITUT (DK) | 2016-08-31 | — | — | EP | disclosed |
| EP-3038614-A1 | COMPOSITION COMPRISING TORASEMIDE AND BACLOFEN FOR TREATING NEUROLOGICAL DISORDERS | Pharnext (FR) | 2016-07-06 | — | — | EP | disclosed |
| EP-2892519-A1 | NOOTROPIC COMPOSITIONS FOR IMPROVING MEMORY PERFORMANCE | Pharnext (FR) | 2015-07-15 | — | — | EP | disclosed |
| EP-2892520-A1 | THERAPEUTIC APPROACHES FOR TREATING EPILEPSY AND RELATED DISORDERS THROUGH REDUCTION OF EPILEPTOGENESIS | Pharnext (FR) | 2015-07-15 | — | — | EP | disclosed |
| WO-2015028659-A1 | COMPOSITION COMPRISING TORASEMIDE AND BACLOFEN FOR TREATING NEUROLOGICAL DISORDERS | PHARNEXT (FR) | 2015-03-05 | — | — | WO | disclosed |
| WO-2014037412-A1 | NOOTROPIC COMPOSITIONS FOR IMPROVING MEMORY PERFORMANCE | PHARNEXT (FR) | 2014-03-13 | — | — | WO | disclosed |
| WO-2014037417-A1 | THERAPEUTIC APPROACHES FOR TREATING EPILEPSY AND RELATED DISORDERS THROUGH REDUCTION OF EPILEPTOGENESIS | PHARNEXT (FR) | 2014-03-13 | — | — | WO | disclosed |
| EP-2181330-B1 | COMPOSITIONS AND MEANS FOR DIAGNOSING MICROBIAL INFECTIONS | STATENS SERUMINSTITUT (DK) | 2013-11-20 | — | — | EP | disclosed |
| WO-2012117075-A2 | TREATMENT OF CEREBRAL ISCHEMIA | PHARNEXT (FR) | 2012-09-07 | — | — | WO | disclosed |
| EP-1303256-A4 | THE COMBINATION OF ANTIMICROBIAL AGENTS AND BACTERIAL INTERFERENCE TO COAT MEDICAL DEVICES | BAYLOR COLLEGE MEDICINE (US) | 2004-04-07 | — | — | EP | disclosed |
| EP-1303256-A1 | THE COMBINATION OF ANTIMICROBIAL AGENTS AND BACTERIAL INTERFERENCE TO COAT MEDICAL DEVICES | Baylor College of Medicine (US) | 2003-04-23 | — | — | EP | disclosed |
| WO-2001095876-A1 | THE COMBINATION OF ANTIMICROBIAL AGENTS AND BACTERIAL INTERFERENCE TO COAT MEDICAL DEVICES | BAYLOR COLLEGE OF MEDICINE (US) | 2001-12-20 | — | — | WO | disclosed |
| US-5668134-A | LOMEFLOXACIN HYDROCHLORIDE | G. D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |