Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfamethoxazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | EDNRA | P25101 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | PPIA | P62937 | 3/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.58 |
| ▸ | EDNRB | P24530 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamethoxazole SCHEMBL6896861 | 1.00 | ALDH1A1 (1.00) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28142856 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL29625775 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL22467841 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28501919 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL5870744 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL1368068 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28565481 | 0.98 | ALDH1A1 (0.97) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL4539943 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ADRA1AMAPTTSHRMAPK1 | |
| Sulfamethoxazole SCHEMBL28003342 | 0.97 | ALDH1A1 (0.94) | ALDH1A1ADRA1AMAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 46825 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747395-A1 | A KIT FOR IDENTIFYING BACTERIA AND DETERMINING ANTIBIOTIC SENSITIVITY | Diagopreutic Private Limited (IN) | 2026-05-27 | — | — | EP | claimed |
| CN-122076457-A | MnFe2O4Application of porous carbon matrix composite material as catalytic material to activate persulfate for degrading sulfonamides | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122076460-A | Metal doped bismuth ferrite based perovskite composite material and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121573820-B | Iron modified algae-based biochar-microalgae hybridization system, preparation method and application | Zhuhai Campus of Beijing Normal University (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122081142-A | Arthropoda pseudolaris X-6 capable of efficiently degrading sulfonamide antibiotics and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-117169187-B | Preparation method of surface-enhanced Raman spectrum substrate for detecting residual of polysulfonamides | 江西农业大学 | 2026-05-22 | — | — | CN | claimed |
| US-20260138981-A1 | DIHYDROFOLATE REDUCTASE INHIBITORS FOR ANTI-BIOTIC RESISTANT INFECTIONS | THE TRUSTEES OF PRINCETON UNIV (US) | 2026-05-21 | — | — | US | claimed |
| EP-4743153-A1 | MEDICAL SYSTEMS FOR TREATING CONDITIONS AND DISEASES OF THE PATIENT'S BODY CAVITIES | UTT Urine Topical Treatment Ltd (IL) | 2026-05-20 | — | — | EP | claimed |
| CN-117129463-B | Flexible SERS sensor for detecting sulfamethoxazole antibiotics and preparation method | 电子科技大学 | 2026-05-19 | — | — | CN | claimed |
| US-4315932-A | AND SULFANILAMIDES | BURROUGHS WELLCOME CO. (US) | 1982-02-16 | — | — | US | claimed |
| US-4303643-A | BACTERICIDES SULFAMETHOXAZOLE AND TRIMETHOPRIM | PFIZER INC. (US) | 1981-12-01 | — | — | US | claimed |
| EP-0037501-A1 | Pharmaceutical preparations and manufacature | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-10-14 | — | — | EP | claimed |
| EP-0035132-A2 | Pharmaceutic preparations with glycerine-alkyl ethers and the use of the latter as pharmaceutical solvents | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-09-09 | — | — | EP | claimed |
| EP-0022342-A2 | Sulfonamide solutions | PFIZER INC. (US) | 1981-01-14 | — | — | EP | claimed |
| US-4209513-A | Tablet formulation | BURROUGHS WELLCOME CO. (US) | 1980-06-24 | — | — | US | claimed |
| US-4169763-A | OF A CORYNEBACTERIA RESISTANT TO ASPARTIC ACID ANALOGS AND SULFA DRUGS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1979-10-02 | — | — | US | claimed |
| US-4122158-A | FOR TREATMENT OF BURNS; BIODEGRADABLE HYDROPHOBIC POLYMER; SUSTAINED RELEASE | ALZA CORPORATION (US) | 1978-10-24 | — | — | US | claimed |
| US-4087528-A | POTENTIATORS OF ANTIBACTERIAL SULFA DRUGS | ABBOTT LABORATORIES (US) | 1978-05-02 | — | — | US | claimed |
| US-3983209-A | HYDROPHOBIC BIOERODIBLE POLYMER, MICROBIOCIDE OR PROTEOLYTIC ENZYME | ALZA CORPORATION (US) | 1976-09-28 | — | — | US | claimed |