Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.52 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28502019 | 0.82 | ACVR1 (0.50) | MAPKAPK2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28505160 | 0.82 | MAPKAPK2 (0.60) | MAPKAPK2MAPK10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL20732829 | 0.82 | MAPKAPK2 (0.60) | MAPKAPK2MAPK10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL31464797 | 0.82 | MAPKAPK2 (0.66) | MAPKAPK2MAPK10PRKDCACVR1BTGFBR1 | |
| SCHEMBL20733053 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL20732831 | 0.80 | MAPKAPK2 (0.55) | MAPKAPK2MAPK10PIK3CAACVR1BTGFBR1 | |
| SCHEMBL20732830 | 0.78 | MAPKAPK2 (0.53) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL24532577 | 0.78 | IP6K1 (0.54) | MAPKAPK2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL8681101 | 0.76 | PIK3CA (0.56) | MAPKAPK2MAPK10PIK3CAACVR1 | |
| SCHEMBL20732922 | 0.76 | MAPKAPK2 (0.53) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111670183-A | Novel heterocyclic compounds as CDK8/19 inhibitors | BIOCAD股份公司 | 2020-09-15 | — | — | CN | claimed |