Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.50 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28505161 | 0.86 | CLK4 (0.46) | ACVR1BMPR1BPDGFRBKITPDGFRA | |
| SCHEMBL28502016 | 0.82 | MAPKAPK2 (0.57) | ACVR1BMPR1BPDGFRBKITPDGFRA | |
| SCHEMBL28799889 | 0.80 | CYP2C19 (0.47) | ACVR1BMPR1BPDGFRBKITPDGFRA | |
| SCHEMBL15638254 | 0.76 | PIK3CA (0.50) | ACVR1BMPR1BPDGFRBKITPDGFRA | |
| SCHEMBL5504565 | 0.72 | ALDH1A3 (0.56) | ACVR1BMPR1BPDGFRBKITPDGFRA | |
| SCHEMBL8681101 | 0.72 | PIK3CA (0.56) | ACVR1MAPKAPK2PIK3CA | |
| SCHEMBL732046 | 0.71 | PIK3CA (0.44) | ACVR1BMPR1BPDGFRBKITPDGFRA | |
| SCHEMBL28019378 | 0.70 | ALDH1A1 (0.48) | ACVR1BMPR1BPDGFRBKITPDGFRA | |
| SCHEMBL29844497 | 0.70 | ALDH1A1 (0.55) | CYP1A2CYP3A4CYP2C19ALDH1A1LMNA | |
| SCHEMBL136563 | 0.70 | ALDH1A1 (0.55) | CYP1A2CYP3A4CYP2C19ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111670183-A | Novel heterocyclic compounds as CDK8/19 inhibitors | BIOCAD股份公司 | 2020-09-15 | — | — | CN | claimed |