Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.51 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28505160 | 0.84 | MAPKAPK2 (0.60) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL31464797 | 0.84 | MAPKAPK2 (0.66) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL28502016 | 0.82 | MAPKAPK2 (0.57) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL20733053 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL20732831 | 0.80 | MAPKAPK2 (0.55) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL20732830 | 0.78 | MAPKAPK2 (0.53) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL20732922 | 0.78 | MAPKAPK2 (0.53) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL28275901 | 0.75 | PIK3CA (0.59) | ACVR1LMNACLK4MAPTCDK8 | |
| SCHEMBL23999520 | 0.73 | MAPKAPK2 (0.54) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B | |
| SCHEMBL30210341 | 0.73 | LGMN (0.53) | MAPKAPK2MAPK10ACVR1BTGFBR1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666770-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | Joint Stock Company "Biocad" (RU) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019031990-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS CDK8/19 INHIBITORS | ЗАКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО "БИОКАД" | 2019-02-14 | — | — | WO | disclosed |