Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28900293 | 0.86 | ADORA2A (0.51) | ADORA2AADORA1 | |
| SCHEMBL28918764 | 0.82 | ADORA2A (0.55) | ADORA2AADORA1ADORA2BMETMAPK14 | |
| SCHEMBL29907652 | 0.82 | ADORA2A (0.66) | ADORA2AADORA1ADORA2BMETATM | |
| SCHEMBL22551964 | 0.82 | ADORA2A (0.66) | ADORA2AADORA1ADORA2BMETATM | |
| SCHEMBL21730362 | 0.78 | ADORA2A (0.68) | ADORA2AADORA1ADORA2B | |
| SCHEMBL29907689 | 0.78 | ADORA2A (0.68) | ADORA2AADORA1ADORA2B | |
| SCHEMBL28470912 | 0.76 | TDP1 (0.38) | ADORA2A | |
| SCHEMBL22551934 | 0.75 | ADORA2A (0.63) | ADORA2AADORA1ADORA2BMETATM | |
| SCHEMBL30880846 | 0.75 | ADORA2A (0.63) | ADORA2AADORA1ADORA2BMETATM | |
| SCHEMBL28804334 | 0.75 | SMN1; SMN2 (0.38) | METROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-112055709-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2020-12-08 | — | — | CN | disclosed |