Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SCNN1A | P37088 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28470912 | 0.85 | TDP1 (0.38) | SMN1; SMN2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5425548 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2KDM4EALDH1A1PKML3MBTL1 | |
| SCHEMBL544545 | 0.76 | CTSA (0.42) | SMN1; SMN2KDM4EALDH1A1PKML3MBTL1 | |
| SCHEMBL29201285 | 0.75 | ADORA2A (0.48) | — | |
| SCHEMBL20560347 | 0.75 | NPC1 (0.44) | SMN1; SMN2KDM4EALDH1A1PKML3MBTL1 | |
| SCHEMBL30170628 | 0.75 | NPC1 (0.44) | SMN1; SMN2KDM4EALDH1A1PKML3MBTL1 | |
| SCHEMBL22552121 | 0.74 | GRM5 (0.48) | SMN1; SMN2KDM4EALDH1A1PKML3MBTL1 | |
| SCHEMBL29988155 | 0.74 | GRM5 (0.48) | SMN1; SMN2KDM4EALDH1A1PKML3MBTL1 | |
| SCHEMBL28466298 | 0.73 | L3MBTL1 (0.44) | SMN1; SMN2KDM4EALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL22551772 | 0.73 | KDM4E (0.40) | SMN1; SMN2KDM4EALDH1A1PKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |