Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21789003 | 0.71 | MTOR (0.58) | GRM7MTORRAB9ACYP3A4ALOX15 | |
| SCHEMBL9513760 | 0.68 | OPRD1 (0.62) | GRM7MTORRAB9ACYP3A4ALOX15 | |
| SCHEMBL28511620 | 0.67 | MAPT (0.48) | TSHROPRD1TDP1HTTNPSR1 | |
| SCHEMBL8095249 | 0.67 | MTOR (1.00) | GRM7MTORRAB9ACYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL3012657 | 0.65 | CYP3A4 (1.00) | GRM7MTORRAB9ACYP3A4ALOX15 | |
| SCHEMBL15591917 | 0.63 | GRM7 (0.65) | GRM7MTORRAB9ACYP3A4ALOX15 | |
| SCHEMBL22321648 | 0.63 | MTOR (0.65) | GRM7MTORRAB9ACYP3A4ALOX15 | |
| SCHEMBL27729884 | 0.63 | MTOR (0.65) | GRM7MTORRAB9ACYP3A4ALOX15 | |
| SCHEMBL10411095 | 0.63 | MTOR (0.81) | GRM7MTORRAB9ACYP3A4ALOX15 | |
| SCHEMBL2074728 | 0.63 | EPHX1 (0.48) | GRM7MTORRAB9ACYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285547-A | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-112004817-B | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-112004817-A | Macrocyclic compounds as modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions thereof, their use in the treatment of cystic fibrosis, and processes for their preparation | 弗特克斯药品有限公司 | 2020-11-27 | — | — | CN | disclosed |