Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25697039 | 0.79 | CYP3A4 (0.53) | CYP3A4ALOX15ALDH1A1LMNAHSD17B10 | |
| SCHEMBL6724867 | 0.78 | MTOR (0.58) | MTORRAB9AGRM7TSHRCYP3A4 | |
| SCHEMBL11368221 | 0.76 | CYP2D6 (0.47) | ATMLMNAPOLBKMT2AMEN1 | |
| SCHEMBL8095249 | 0.74 | MTOR (1.00) | MTORRAB9AGRM7TSHRCYP3A4 | |
| SCHEMBL11087718 | 0.74 | MTOR (0.52) | MTORRAB9AGRM7TSHRCYP3A4 | |
| SCHEMBL8524972 | 0.72 | LMNA (0.50) | RAB9ATSHRCYP3A4ALOX15ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3012657 | 0.72 | CYP3A4 (1.00) | MTORRAB9AGRM7TSHRCYP3A4 | |
| SCHEMBL28504259 | 0.71 | GRM7 (0.48) | MTORRAB9AGRM7TSHRCYP3A4 | |
| SCHEMBL2074728 | 0.70 | EPHX1 (0.48) | MTORRAB9AGRM7TSHRCYP3A4 | |
| SCHEMBL10411095 | 0.70 | MTOR (0.81) | MTORRAB9AGRM7TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |