Phosphine

Phosphine

SCHEMBL28505016

NC(Cc1ccccc1)(c1ccccc1)c1ccccc1.P

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.56
TAAR1 Q96RJ0 1/20 0.56
CYP1A2 P05177 2/20 0.54
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.50
HIF1A Q16665 1/20 0.50
KCNN4 O15554 1/20 0.48
KIF11 P52732 4/20 0.47
LOXL2 Q9Y4K0 1/20 0.42
LMNA P02545 1/20 0.41
CYP2D6 P10635 1/20 0.41
KCNA5 P22460 1/20 0.41
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
CYP3A4 P08684 1/20 0.41
RECQL P46063 1/20 0.41
ARG1 P05089 1/20 0.40
ARG2 P78540 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2573964 0.97 TAAR1 (0.58) SLC6A2TAAR1CYP1A2CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL11784213 0.95 SLC6A2 (0.56) SLC6A2TAAR1CYP1A2CYP2C9CYP2C19
Bromide SCHEMBL28902281 0.95 SLC6A2 (0.56) SLC6A2TAAR1CYP1A2CYP2C9CYP2C19
Water SCHEMBL11128724 0.95 SLC6A2 (0.56) SLC6A2TAAR1CYP1A2CYP2C9CYP2C19
SCHEMBL28287638 0.82 KIF11 (0.54) SLC6A2TAAR1CYP1A2CYP2C9CYP2C19
SCHEMBL6682555 0.82 KIF11 (0.50) SLC6A2TAAR1CYP1A2CYP2C9CYP2C19
SCHEMBL17964410 0.80 LTA4H (0.53) SLC6A2TAAR1SMN1; SMN2KIF11LMNA
SCHEMBL759856 0.80 SLC6A2 (0.56) SLC6A2TAAR1CYP1A2CYP2C9CYP2C19
SCHEMBL28819441 0.80 SLC6A2 (0.56) SLC6A2TAAR1CYP1A2CYP2C9CYP2C19
SCHEMBL2406230 0.80 SLC6A2 (0.56) SLC6A2TAAR1CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112961331-B Polymers, methods, compositions and uses 科思创(荷兰)有限公司 2022-10-21 CN disclosed
CN-113045968-B Polymers, methods, compositions and uses 科思创(荷兰)有限公司 2022-10-21 CN disclosed
CN-109312060-B Polymers, methods, compositions and uses 帝斯曼知识产权资产管理有限公司 2021-07-27 CN disclosed
CN-113045968-A Polymers, methods, compositions and uses 帝斯曼知识产权资产管理有限公司 2021-06-29 CN disclosed
CN-112961331-A Polymers, methods, compositions and uses 帝斯曼知识产权资产管理有限公司 2021-06-15 CN disclosed
CN-109790282-B Polymers, methods, compositions and uses 帝斯曼知识产权资产管理有限公司 2021-04-02 CN disclosed
CN-109153774-B Polymers, methods, compositions and uses 帝斯曼知识产权资产管理有限公司 2020-12-25 CN disclosed