Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | P4HB | P07237 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 8/20 | 0.42 |
| ▸ | LPL | P06858 | 7/20 | 0.42 |
| ▸ | CA1 | P00915 | 6/20 | 0.42 |
| ▸ | CA2 | P00918 | 6/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.42 |
| ▸ | F11 | P03951 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28513866 | 0.92 | LIPG (0.40) | HDAC4P4HBLIPGLPLCA1 | |
| SCHEMBL4097075 | 0.90 | MTOR (0.49) | CA1CA2CA9CA12CA3 | |
| SCHEMBL22922489 | 0.89 | HDAC4 (0.43) | HDAC4P4HBLIPGLPLCA1 | |
| SCHEMBL15464280 | 0.85 | HDAC4 (0.46) | HDAC4P4HBLIPGLPLCA1 | |
| SCHEMBL22859207 | 0.83 | CA1 (0.41) | HDAC4P4HBLIPGLPLCA1 | |
| SCHEMBL2802162 | 0.83 | HIF1A (0.36) | HDAC4P4HBLIPGLPLCA1 | |
| SCHEMBL1290961 | 0.82 | P4HB (0.48) | P4HBLIPGLPLCA1CA2 | |
| SCHEMBL12781285 | 0.81 | LPL (0.49) | P4HBLIPGLPLCA1CA2 | |
| SCHEMBL25393242 | 0.81 | P4HB (0.42) | P4HBLIPGLPLCA1CA2 | |
| SCHEMBL22858732 | 0.81 | FFAR1 (0.43) | P4HBLIPGLPLCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |