Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.57 |
| ▸ | F2 | P00734 | 4/20 | 0.57 |
| ▸ | C1S | P09871 | 1/20 | 0.57 |
| ▸ | PLG | P00747 | 1/20 | 0.57 |
| ▸ | F10 | P00742 | 3/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | F12 | P00748 | 1/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31021028 | 0.88 | PARP1 (0.73) | PARP1F7F3POLBCYP3A4 | |
| SCHEMBL15547311 | 0.88 | PRSS1 (0.70) | PRSS1PRSS2PRSS3F2C1S | |
| SCHEMBL36694 | 0.88 | PARP1 (0.73) | PARP1F7F3POLBCYP3A4 | |
| SCHEMBL9271119 | 0.86 | ATM (0.60) | PRSS1PRSS2PRSS3F2C1S | |
| Hydrochloric Acid SCHEMBL28555629 | 0.85 | PRSS1 (0.74) | PRSS1PRSS2PRSS3F2C1S | |
| Hydrochloric Acid SCHEMBL1367509 | 0.85 | PARP1 (0.70) | PARP1F7F3POLBCYP3A4 | |
| Methane SCHEMBL688609 | 0.85 | PARP1 (0.70) | PARP1F7F3POLBCYP3A4 | |
| Water SCHEMBL7768285 | 0.85 | PARP1 (0.70) | PARP1F7F3POLBCYP3A4 | |
| Ammonia Solution, Strong SCHEMBL9121446 | 0.85 | PARP1 (0.70) | PARP1F7F3POLBCYP3A4 | |
| Hydrochloric Acid SCHEMBL28253026 | 0.85 | PRSS1 (0.74) | PRSS1PRSS2PRSS3F2C1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |
| EP-0976722-B1 | BENZAMIDINE DERIVATIVES | AJINOMOTO KK (JP) | 2009-03-11 | — | — | EP | disclosed |
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-7223782-B2 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | SCN3A, TRPV3, HCN3 | PARP1 3600/4885PRSS1 835/4885PRSS2 1361/4885 |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | SCN3A, TRPV3, HCN3 | PARP1 3600/4885PRSS1 835/4885PRSS2 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.