Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28509010 | 1.00 | POLB (0.50) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL31184543 | 1.00 | POLB (0.50) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL31185020 | 0.95 | POLB (0.47) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL31184662 | 0.95 | POLB (0.47) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL31184536 | 0.89 | POLB (0.51) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL31185017 | 0.86 | POLB (0.56) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL31184625 | 0.86 | POLB (0.49) | POLBALDH1A1SMN1; SMN2GAALMNA | |
| SCHEMBL31184825 | 0.83 | ALDH1A1 (0.52) | POLBALDH1A1SMN1; SMN2GAALMNA | |
| SCHEMBL31184928 | 0.83 | POLB (0.57) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL29198309 | 0.81 | MALT1 (0.42) | POLBALDH1A1SMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112074511-B | Substituted benzodiazoles and their use in therapy | 托马斯·黑勒戴药物研究基金会 | 2024-04-26 | — | — | CN | disclosed |
| CN-112074511-A | Substituted benzodiazoles and their use in therapy | 托马斯·黑勒戴药物研究基金会 | 2020-12-11 | — | — | CN | disclosed |