Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.61 |
| ▸ | IKBKB | O14920 | 2/20 | 0.61 |
| ▸ | CHUK | O15111 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | INSR | P06213 | 2/20 | 0.61 |
| ▸ | CDK2 | P24941 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.61 |
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.51 |
| ▸ | SGK1 | O00141 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298617 | 0.96 | MAP3K11 (0.58) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL7874310 | 0.87 | FGFR1 (0.49) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL15154791 | 0.86 | MAP3K11 (0.80) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL299467 | 0.83 | CD274 (0.51) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL12965684 | 0.83 | INSR (0.64) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL29178532 | 0.81 | FGFR1 (0.50) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL31023220 | 0.78 | CHEK1 (0.46) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL4786065 | 0.77 | LTA4H (0.51) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL31023203 | 0.77 | FAAH (0.45) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL12067524 | 0.77 | MAP3K11 (1.00) | MAP3K11IKBKBCHUKABL1INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. | 2012-05-17 | — | — | US | disclosed |
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. | 2012-05-17 | — | — | US | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | BRAF, RAF1, ARAF | MAP3K11 37/4885IKBKB 475/4885CHUK 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.