Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAP2 | P11137 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28518771 | 0.85 | MAP2 (0.40) | NPSR1MAP2ALOX5APFEN1KDM4E | |
| SCHEMBL28517414 | 0.80 | MAP2 (0.40) | TRPA1POLBNPSR1MAP2SCN9A | |
| SCHEMBL8849705 | 0.70 | RORC (0.41) | TRPA1POLBNPSR1MAP2SCN9A | |
| SCHEMBL14744380 | 0.68 | ALOX5AP (0.47) | TRPA1POLBNPSR1MAP2SCN9A | |
| SCHEMBL28518808 | 0.65 | ALOX5AP (0.35) | TRPA1SCN9AALOX5APFEN1RORC | |
| SCHEMBL7701143 | 0.65 | ALDH1A1 (0.50) | TRPA1POLBNPSR1SCN9AALOX5AP | |
| SCHEMBL14744191 | 0.63 | RORC (0.44) | MAP2ALOX5APFEN1RORCMPL | |
| SCHEMBL14744553 | 0.63 | ALOX5AP (0.43) | MAP2SCN9AALOX5APFEN1RORC | |
| SCHEMBL30026290 | 0.63 | BRD4 (0.46) | NPSR1MAP2ALOX5APFEN1KDM4E | |
| SCHEMBL8849701 | 0.62 | SCN9A (0.40) | TRPA1POLBNPSR1SCN9AALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514722-A | Benzimidazole derivatives as modulators of retinoic acid related orphan receptor gamma (ROR gamma) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-112135611-B | Benzimidazole derivatives as modulators of retinoic acid-related orphan receptor gamma (ROR γ) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-112135611-A | Benzimidazole derivatives as modulators of retinoic acid-related orphan receptor gamma (ROR γ) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2020-12-25 | — | — | CN | disclosed |