Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 14/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.38 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28518808 | 0.85 | ALOX5AP (0.35) | RORCTRPA1SCN9A | |
| SCHEMBL23451923 | 0.84 | MAP2 (0.38) | MAP2NPSR1 | |
| SCHEMBL28517220 | 0.83 | RORC (0.36) | MAP2RORCTRPA1 | |
| SCHEMBL28522522 | 0.81 | TRPA1 (0.44) | TRPA1CYP2C9 | |
| SCHEMBL28505135 | 0.81 | MAP2 (0.41) | MAP2RORCTRPA1NPSR1CYP2C9 | |
| SCHEMBL28517230 | 0.81 | PDE5A (0.37) | — | |
| SCHEMBL28510942 | 0.80 | DHODH (0.34) | TRPA1CYP2C9 | |
| SCHEMBL28511196 | 0.80 | TRPA1 (0.39) | MAP2RORCTRPA1POLBNPSR1 | |
| SCHEMBL30026262 | 0.80 | SCN9A (0.41) | MAP2RORCTRPA1GRIA1CACNG8 | |
| SCHEMBL28514043 | 0.78 | FFAR2 (0.35) | POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514722-A | Benzimidazole derivatives as modulators of retinoic acid related orphan receptor gamma (ROR gamma) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-112135611-B | Benzimidazole derivatives as modulators of retinoic acid-related orphan receptor gamma (ROR γ) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-112135611-A | Benzimidazole derivatives as modulators of retinoic acid-related orphan receptor gamma (ROR γ) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2020-12-25 | — | — | CN | disclosed |