Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30507451 | 0.80 | PAX8 (0.38) | KDM4EGAAMAPTPAX8ALDH1A1 | |
| SCHEMBL3581496 | 0.80 | TSHR (0.42) | KDM4EGAAPAX8ALDH1A1 | |
| SCHEMBL28514334 | 0.79 | NPC1 (0.46) | KDM4EMAPTALDH1A1 | |
| SCHEMBL29389836 | 0.77 | LMNA (0.36) | MAPTPAX8ALDH1A1 | |
| SCHEMBL23662177 | 0.73 | PAX8 (0.39) | PAX8USP30 | |
| SCHEMBL28513305 | 0.73 | KDM4E (0.34) | KDM4EGAAMAPT | |
| SCHEMBL3584305 | 0.71 | SCD (0.52) | — | |
| SCHEMBL14568860 | 0.70 | LCK (0.64) | — | |
| SCHEMBL28511505 | 0.69 | ADORA2A (0.37) | PAX8ALDH1A1GLAUSP30 | |
| SCHEMBL210860 | 0.68 | DHODH (0.38) | KDM4EGAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112010844-B | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-112010844-A | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2020-12-01 | — | — | CN | disclosed |