Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 11/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30641871 | 0.85 | MAPK1 (0.54) | MAPK1DYRK1ARIPK1JAK2JAK3 | |
| SCHEMBL28513749 | 0.85 | MAPK1 (0.54) | MAPK1DYRK1ARIPK1JAK2JAK3 | |
| SCHEMBL28502428 | 0.83 | RIPK1 (0.54) | MAPK1DYRK1ARIPK1XDHROCK2 | |
| SCHEMBL28513876 | 0.83 | MAPK1 (0.55) | MAPK1DYRK1ARIPK1 | |
| SCHEMBL28508679 | 0.80 | MAPK1 (0.59) | MAPK1DYRK1ARIPK1CHEK1 | |
| SCHEMBL28906226 | 0.80 | ROCK2 (0.47) | DYRK1AXDHROCK2ROCK1CDC42BPB | |
| SCHEMBL21590171 | 0.80 | RIPK1 (0.50) | MAPK1DYRK1ARIPK1XDHROCK2 | |
| SCHEMBL28504401 | 0.77 | MAPK1 (0.55) | MAPK1DYRK1ARIPK1JAK2JAK3 | |
| SCHEMBL29888818 | 0.76 | MAPK1 (0.56) | MAPK1DYRK1ARIPK1 | |
| SCHEMBL28769143 | 0.76 | MAPK1 (0.56) | MAPK1DYRK1ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |