Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 11/20 | 0.55 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | IL2 | P60568 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28513565 | 0.88 | MAPK1 (0.53) | MAPK1MAP4K1DYRK1ARIPK1IL2 | |
| SCHEMBL28513749 | 0.85 | MAPK1 (0.54) | MAPK1MAP4K1DYRK1ARIPK1 | |
| SCHEMBL30641871 | 0.85 | MAPK1 (0.54) | MAPK1MAP4K1DYRK1ARIPK1 | |
| SCHEMBL28504554 | 0.83 | BRD4 (0.58) | MAPK1MAP4K1DYRK1ARIPK1IL2 | |
| SCHEMBL28514903 | 0.83 | MAPK1 (0.51) | MAPK1DYRK1ARIPK1 | |
| SCHEMBL28508679 | 0.80 | MAPK1 (0.59) | MAPK1MAP4K1DYRK1ARIPK1MAPT | |
| SCHEMBL28508735 | 0.80 | MAP4K1 (0.61) | MAP4K1IL2MEN1CYP1A2CYP2D6 | |
| SCHEMBL15542823 | 0.80 | MAPK1 (0.70) | MAPK1DYRK1ARIPK1 | |
| SCHEMBL29086750 | 0.78 | MAPK1 (0.52) | MAPK1MAP4K1DYRK1ARIPK1TNIK | |
| SCHEMBL28504401 | 0.77 | MAPK1 (0.55) | MAPK1DYRK1ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |