Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 9/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 5/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 7/20 | 0.35 |
| ▸ | AXL | P30530 | 4/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1791793 | 0.82 | FLT3 (0.60) | FLT3KDR | |
| SCHEMBL409724 | 0.82 | MET (0.55) | CSF1RFLT3MERTKTRPA1MET | |
| SCHEMBL28509383 | 0.80 | CSF1R (0.37) | CSF1RFLT3MERTKMETAXL | |
| SCHEMBL30466546 | 0.79 | MERTK (0.58) | CSF1RFLT3MERTKMETAXL | |
| SCHEMBL21219874 | 0.79 | MERTK (0.58) | CSF1RFLT3MERTKMETAXL | |
| SCHEMBL1791378 | 0.77 | TRPA1 (0.40) | CSF1RFLT3MERTKTRPA1MET | |
| SCHEMBL2198672 | 0.76 | CYP3A4 (0.37) | CSF1RFLT3MERTKTRPA1MET | |
| SCHEMBL28516905 | 0.75 | MET (0.39) | MERTKMETAXL | |
| SCHEMBL409483 | 0.73 | MET (0.62) | FLT3MERTKTRPA1METAXL | |
| SCHEMBL28529593 | 0.73 | MET (0.43) | MERTKMETAXLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112312909-B | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-112312909-A | Compounds for the treatment of kinase-dependent disorders | 埃克塞里艾克西斯公司 | 2021-02-02 | — | — | CN | disclosed |