Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.62 |
| ▸ | MET | P08581 | 10/20 | 0.48 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.46 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL487842 | 0.85 | JAK2 (0.60) | JAK2METMAP4K3CYP11B1CYP11B2 | |
| SCHEMBL30453168 | 0.85 | JAK2 (0.60) | JAK2METMAP4K3CYP11B1CYP11B2 | |
| SCHEMBL28036128 | 0.84 | JAK2 (0.47) | JAK2METMAP4K3 | |
| SCHEMBL28035735 | 0.82 | JAK2 (0.47) | JAK2METMAP4K3 | |
| SCHEMBL28924806 | 0.81 | JAK2 (0.44) | JAK2METMAP4K3 | |
| SCHEMBL3687014 | 0.81 | MET (0.48) | JAK2METMAP4K3 | |
| SCHEMBL28643808 | 0.80 | MET (0.47) | JAK2METMAP4K3 | |
| SCHEMBL28518564 | 0.80 | JAK2 (0.51) | JAK2METMAP4K3EPHB4 | |
| SCHEMBL14812299 | 0.80 | MET (0.54) | JAK2METMAP4K3 | |
| SCHEMBL1823431 | 0.79 | MET (0.57) | JAK2METMAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112119070-B | Selective JAK2 inhibitors and uses thereof | 华东理工大学 | 2023-02-17 | — | — | CN | disclosed |
| CN-112119070-A | Selective JAK2 inhibitor and application thereof | 华东理工大学 | 2020-12-22 | — | — | CN | disclosed |