SCHEMBL28515932

SCHEMBL28515932

CCC(C(=O)N1CCCC[C@@]1(C(=O)O)C(CCc1ccc(OC)c(OC)c1)c1cccc(O)c1)c1cc(OC)c(OC)c(OC)c1

nearest known ligand 0.49

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 14/20 0.49
FKBP5 Q13451 7/20 0.43
FKBP1B P68106 1/20 0.42
FKBP4 Q02790 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28520202 0.86 FKBP1A (0.54) FKBP1AFKBP5FKBP4
SCHEMBL29827870 0.83 FKBP1A (0.47) FKBP1AFKBP5FKBP4
SCHEMBL29827767 0.73 FKBP1A (0.40) FKBP1AFKBP5
SCHEMBL24685955 0.69 FKBP1A (0.81) FKBP1AFKBP5FKBP1BFKBP4
SCHEMBL609094 0.68 FKBP1A (0.50) FKBP1AFKBP5FKBP4
SCHEMBL27064367 0.67 FKBP1A (0.80) FKBP1AFKBP5FKBP1BFKBP4
SCHEMBL15597349 0.67 FKBP1A (0.80) FKBP1AFKBP5FKBP1BFKBP4
SCHEMBL22221420 0.67 FKBP1A (0.75) FKBP1AFKBP5FKBP1BFKBP4
SCHEMBL16975607 0.67 FKBP1A (0.91) FKBP1AFKBP5FKBP1BFKBP4
SCHEMBL18379659 0.66 FKBP1A (0.72) FKBP1AFKBP5FKBP1BFKBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112409376-A Protein degradation targeting chimera based on DCAF15, and preparation method and application thereof 华东师范大学 2021-02-26 CN disclosed