Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 10/20 | 0.46 |
| ▸ | DHODH | Q02127 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30116420 | 1.00 | RHEB (0.46) | RHEBDHODHTDP1PRKAG1PRKAA2 | |
| SCHEMBL28511997 | 0.88 | RHEB (0.48) | RHEBTDP1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL30116444 | 0.88 | RHEB (0.48) | RHEBTDP1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL28508944 | 0.84 | TRPA1 (0.44) | RHEBTDP1 | |
| SCHEMBL30116523 | 0.84 | TRPA1 (0.44) | RHEBTDP1 | |
| SCHEMBL30116414 | 0.82 | RHEB (0.53) | RHEB | |
| SCHEMBL28508959 | 0.82 | RHEB (0.44) | RHEBTDP1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL28517848 | 0.82 | RHEB (0.53) | RHEB | |
| SCHEMBL23000280 | 0.72 | SCD (0.43) | DHODH | |
| SCHEMBL28510942 | 0.71 | DHODH (0.34) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514722-A | Benzimidazole derivatives as modulators of retinoic acid related orphan receptor gamma (ROR gamma) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-112135611-B | Benzimidazole derivatives as modulators of retinoic acid-related orphan receptor gamma (ROR γ) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-112135611-A | Benzimidazole derivatives as modulators of retinoic acid-related orphan receptor gamma (ROR γ) and pharmaceutical uses thereof | 江苏恒瑞医药股份有限公司 | 2020-12-25 | — | — | CN | disclosed |