Sugi Predict

Sugi Predict / Compounds / SCHEMBL28517837

SCHEMBL28517837

SCHEMBL28517837

CC(C)(C)OC(=O)NCc1ccc(OCc2ccc(F)cc2)nc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ GRM2 Q14416 1/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.46
▸ HDAC1 Q13547 1/20 0.44
▸ NAMPT P43490 1/20 0.43
▸ HPGD P15428 1/20 0.42
▸ CTSS P25774 1/20 0.42
▸ CTSK P43235 1/20 0.42
▸ CXCR2 P25025 1/20 0.42
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ GAA P10253 2/20 0.41
▸ FAAH O00519 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ GPR119 Q8TDV5 1/20 0.41
▸ GRM5 P41594 1/20 0.41
▸ CYP3A4 P08684 1/20 0.40
▸ POLB P06746 1/20 0.40
▸ GABRA5 P31644 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27382466 0.89 MEN1 (0.51) L3MBTL1HDAC1NAMPTMEN1KMT2A
SCHEMBL21492472 0.82 CXCR2 (0.49) L3MBTL1CXCR2GAALMNAMAPT
SCHEMBL30625710 0.82 L3MBTL1 (0.51) L3MBTL1HDAC1NAMPTGAAMAPT
SCHEMBL10264861 0.82 L3MBTL1 (0.51) L3MBTL1HDAC1NAMPTGAAMAPT
SCHEMBL1444314 0.82 HPGD (0.59) GRM2L3MBTL1NAMPTHPGDCTSS
SCHEMBL31473369 0.81 FAAH (0.47) GRM2L3MBTL1NAMPTFAAHPOLB
SCHEMBL27295443 0.81 FAAH (0.47) GRM2L3MBTL1NAMPTFAAHPOLB
SCHEMBL27300364 0.81 GRM2 (0.43) GRM2L3MBTL1HDAC1NAMPTGAA
SCHEMBL29859843 0.81 L3MBTL1 (0.52) GRM2L3MBTL1HDAC1NAMPTMEN1
SCHEMBL31087465 0.81 L3MBTL1 (0.47) L3MBTL1NAMPTMAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12384790-B2 Pteridinone compounds and uses thereof VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-08-12 — — US disclosed
US-20230312587-A1 PTERIDINONE COMPOUNDS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2023-10-05 — — US disclosed
US-11572364-B2 Pteridinone compounds and uses thereof VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-02-07 — — US disclosed
US-20220363685-A1 PTERIDINONE COMPOUNDS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2022-11-17 — — US disclosed
CN-112218865-A Pteridinone compounds and uses thereof 沃泰克斯药物股份有限公司 2021-01-12 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11572364-B2 Pteridinone compounds and uses thereof DPYD, PKD1, TYMP GRM2 2976/4885L3MBTL1 4437/4885HDAC1 1240/4885
US-20220363685-A1 PTERIDINONE COMPOUNDS AND USES THEREOF DPYD, PKD1, TYMP GRM2 2976/4885L3MBTL1 4437/4885HDAC1 1240/4885
US-20230312587-A1 PTERIDINONE COMPOUNDS AND USES THEREOF DPYD, PKD1, TYMP GRM2 2976/4885L3MBTL1 4437/4885HDAC1 1240/4885
US-12384790-B2 Pteridinone compounds and uses thereof DPYD, PKD1, TYMP GRM2 2976/4885L3MBTL1 4437/4885HDAC1 1240/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.