SCHEMBL31473369

SCHEMBL31473369

CC(C)(C)OC(=O)NCc1ccc(Oc2ccc(F)cc2F)nc1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.47
HSPB1 P04792 1/20 0.46
GRM2 Q14416 1/20 0.43
CARM1 Q86X55 4/20 0.42
PRMT6 Q96LA8 3/20 0.42
KDM4E B2RXH2 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
AXL P30530 1/20 0.41
NAMPT P43490 1/20 0.40
MAPK14 Q16539 1/20 0.39
SCN9A Q15858 1/20 0.39
POLB P06746 1/20 0.39
P2RX3 P56373 2/20 0.39
RXRB P28702 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27295443 1.00 FAAH (0.47) FAAHHSPB1GRM2CARM1PRMT6
SCHEMBL27300364 0.92 GRM2 (0.43) FAAHGRM2CARM1PRMT6L3MBTL1
SCHEMBL27300023 0.90 GAA (0.43) L3MBTL1NAMPTP2RX3RXRB
SCHEMBL31473430 0.89 SCN9A (0.47) FAAHGRM2CARM1PRMT6L3MBTL1
SCHEMBL27295180 0.89 SCN9A (0.47) FAAHGRM2CARM1PRMT6L3MBTL1
SCHEMBL27300452 0.87 L3MBTL1 (0.43) FAAHGRM2L3MBTL1NAMPT
SCHEMBL30392991 0.85 CARM1 (0.45) FAAHGRM2CARM1PRMT6L3MBTL1
SCHEMBL27299733 0.85 SCN9A (0.46) FAAHGRM2CARM1PRMT6L3MBTL1
SCHEMBL30391882 0.82 HSPB1 (0.56) HSPB1GRM2CARM1PRMT6KDM4E
SCHEMBL27299801 0.82 EGLN1 (0.43) GRM2CARM1PRMT6L3MBTL1NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119866333-A KIT inhibitors, compounds, pharmaceutical compositions, and methods of use thereof 亚力维克希斯股份有限公司 2025-04-22 CN disclosed