Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16029234 | 0.87 | OPRK1 (0.44) | OPRK1HPGDALDH1A1LMNAKDM4E | |
| SCHEMBL27696475 | 0.83 | HPGD (0.47) | OPRK1HPGDALDH1A1LMNAKDM4E | |
| SCHEMBL18179511 | 0.82 | ACHE (0.42) | HPGDALDH1A1LMNAKDM4EACHE | |
| SCHEMBL659599 | 0.76 | HPGD (0.46) | OPRK1HPGDALDH1A1LMNAKDM4E | |
| SCHEMBL16912027 | 0.75 | ACHE (0.49) | OPRK1HPGDALDH1A1LMNAKDM4E | |
| SCHEMBL1140333 | 0.74 | ALDH1A1 (0.46) | HPGDALDH1A1LMNAKDM4EHTT | |
| SCHEMBL18380630 | 0.74 | FFAR1 (0.52) | ACHE | |
| SCHEMBL25464716 | 0.73 | OPRK1 (0.43) | OPRK1SMN1; SMN2RAB9A | |
| SCHEMBL12993521 | 0.73 | ELANE (0.36) | ALDH1A1LMNAKDM4EACHERAB9A | |
| SCHEMBL1581745 | 0.73 | ELANE (0.36) | ALDH1A1LMNAKDM4EACHERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112218857-B | P300/CBP HAT inhibitors and methods of use thereof | 星座制药公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-114450005-A | Compounds for the treatment of neurological disorders | 星座制药公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-112218857-A | P300/CBP HAT inhibitors and methods of use thereof | 星座制药公司 | 2021-01-12 | — | — | CN | disclosed |