Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.55 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.55 |
| ▸ | PDE4A | P27815 | 3/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28518021 | 0.88 | PDE4A (0.56) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL28522379 | 0.85 | PDE4A (0.53) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL28511048 | 0.75 | AGTR1 (0.36) | AGTR1AGTR2SIRT5LMNAHSD17B10 | |
| SCHEMBL9593298 | 0.75 | AGTR1 (0.75) | AGTR1AGTR2SIRT5NPSR1MEN1 | |
| SCHEMBL28520507 | 0.74 | RAB9A (0.36) | AGTR1AGTR2SIRT5MEN1ALDH1A1 | |
| SCHEMBL28525183 | 0.73 | ALDH1A1 (0.44) | MEN1ALDH1A1LMNATP53TSHR | |
| SCHEMBL9590611 | 0.71 | AGTR1 (0.76) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL28518879 | 0.70 | SMN1; SMN2 (0.58) | AGTR1AGTR2SIRT5NPSR1MEN1 | |
| SCHEMBL34462302 | 0.70 | AGTR1 (0.51) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9592095 | 0.70 | AGTR1 (0.69) | AGTR1AGTR2SIRT5NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106279044-B | Pyrimidine hydroxamic acid derivative and preparation method and application thereof | 厦门市博瑞来医药科技有限公司 | 2021-02-19 | — | — | CN | disclosed |