Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18363126 | 0.80 | CDK8 (0.44) | AXLGSK3BCDK8MAP4K4TNIK | |
| SCHEMBL29953852 | 0.76 | AXL (0.43) | AXLGSK3BCDK8MAP4K4TNIK | |
| SCHEMBL28518315 | 0.75 | GRIN2B (0.48) | GRIN2B | |
| SCHEMBL18363121 | 0.72 | DYRK1A (0.44) | GSK3BCDK8MAP4K4PLK4PRKD3 | |
| SCHEMBL29377991 | 0.69 | KDM4E (0.65) | AXLCDK8MAP4K4ALDH1A1NPSR1 | |
| SCHEMBL28081897 | 0.69 | KDM4E (0.65) | AXLCDK8MAP4K4ALDH1A1NPSR1 | |
| SCHEMBL13552132 | 0.68 | ACACB (0.34) | — | |
| SCHEMBL23300377 | 0.67 | ALDH1A1 (0.53) | AXLGSK3BCDK8MAP4K4TNIK | |
| SCHEMBL18363124 | 0.67 | AXL (0.54) | AXLGSK3BCDK8MAP4K4TNIK | |
| SCHEMBL31665907 | 0.67 | PIK3CD (0.54) | AXLGSK3BCDK8MAP4K4TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026094-B | Substituted 4-azaindoles and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2021-02-09 | — | — | CN | disclosed |