Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29351775 | 0.95 | MEN1 (0.55) | MEN1KMT2AKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL22529955 | 0.95 | MEN1 (0.55) | MEN1KMT2AKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL15044215 | 0.92 | KDM4E (0.54) | MEN1KMT2AKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL28418217 | 0.84 | LMNA (0.56) | KDM4EL3MBTL1SMN1; SMN2POLBRAB9A | |
| SCHEMBL29350393 | 0.82 | PKM (0.45) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL22529935 | 0.82 | PKM (0.45) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL30689304 | 0.81 | P2RX3 (0.47) | MEN1KMT2AKDM4EHTTP2RX3 | |
| SCHEMBL3022633 | 0.79 | FFAR1 (0.46) | HSPB1KCNH2SCN5ASCN9A | |
| SCHEMBL778928 | 0.79 | MEN1 (0.64) | MEN1KMT2AKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL4504068 | 0.78 | MEN1 (0.54) | MEN1KMT2AKDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112218865-B | Pteridinone compounds and uses thereof | 沃泰克斯药物股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-112218865-A | Pteridinone compounds and uses thereof | 沃泰克斯药物股份有限公司 | 2021-01-12 | — | — | CN | disclosed |