Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28524818 | 0.90 | ALDH1A1 (0.42) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL28533016 | 0.88 | EGLN1 (0.41) | SMN1; SMN2LMNAALDH1A1TP53MAPT | |
| SCHEMBL28525183 | 0.75 | ALDH1A1 (0.44) | SMN1; SMN2LMNAALDH1A1HTTHPGD | |
| SCHEMBL28518879 | 0.74 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL28511046 | 0.73 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL28520505 | 0.72 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL28524820 | 0.71 | ALDH1A1 (0.44) | SMN1; SMN2LMNAALDH1A1HTTMAPT | |
| SCHEMBL1014833 | 0.71 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL30879308 | 0.70 | MAPT (0.80) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL28533018 | 0.70 | HSD17B10 (0.44) | SMN1; SMN2LMNAALDH1A1HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106279044-B | Pyrimidine hydroxamic acid derivative and preparation method and application thereof | 厦门市博瑞来医药科技有限公司 | 2021-02-19 | — | — | CN | disclosed |