Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.37 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.37 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138024 | 0.86 | PARP1 (0.38) | — | |
| SCHEMBL28525830 | 0.84 | KDM4E (0.43) | MAPTKDM4ETHRBPDE4BHRH3 | |
| SCHEMBL24583551 | 0.76 | CDK7 (0.47) | MAPTKDM4ETHRBDDB1CRBN | |
| SCHEMBL28297779 | 0.74 | PDE4B (0.56) | MAPTKDM4ETHRBPDE4BDPP4 | |
| SCHEMBL28298497 | 0.74 | PDE4B (0.56) | MAPTKDM4ETHRBPDE4BDPP4 | |
| SCHEMBL22619116 | 0.73 | PDE4B (0.53) | MAPTKDM4ETHRBPDE4BHRH3 | |
| SCHEMBL26985427 | 0.71 | PDE4B (0.58) | MAPTKDM4ETHRBPDE4BHRH3 | |
| SCHEMBL28533641 | 0.71 | CREBBP (0.35) | — | |
| SCHEMBL20439010 | 0.71 | KDM4E (0.55) | MAPTKDM4ETHRBPDE4BHRH3 | |
| SCHEMBL28593500 | 0.70 | PDE4B (0.54) | MAPTKDM4ETHRBPDE4BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107873031-B | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2021-03-12 | — | — | CN | disclosed |